When employing the CBPR research approach, it is crucial to recognize the pervasive influence of systemic white supremacy, as it creates significant obstacles in achieving inclusive and antiracist CBPR collaborations. White supremacy has “been created and constructed over centuries to value the lives, institutions, and knowledge of White people and devalue the human dignity and lives of Black, Indigenous, Latinx, Arab, Asian, and other marginalized groups” (Fleming, Paul J, et al). For instance, sickle cell disease, which predominantly affects black Americans, receives considerably less attention and support from the NIH and US philanthropic organizations compared to diseases that are more prevalent in the white population (Fleming, Paul J, et al). The public health critical race praxis (PHCR) is an antiracism framework for health research that aims to uncover and address the root causes of racial hierarchies by incorporating principles from critical race theory (CRT) into health research, with the aim of promoting antiracist approaches. PHCR principles thus align with CBPR’s focus on prioritizing the empowerment of marginalized communities and actively working to dismantle various forms of inequities (Fleming, Paul J, et al).